Fig. 1 · Structure
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ARN14686
NAAA Inhibitor
ARN14686 is a potent inhibitor of the N-acylethanolamine hydrolyzing acid amidase (NAAA), demonstrating an impressive IC50 value of 0.006 μM. This compound interacts with NAAA through covalent binding to the N-terminal cysteine, selectively targeting the catalytically active form of the enzyme. ARN14686 serves as an effective activity-based protein profiling (ABPP) probe, facilitating the study of NAAA's biological functions and its potential role in various research applications such as neurobiology and metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1628345-10-7 |
| Applications | NAAA Inhibitor |
| Formula | C15H24N2O3 |
| Molecular Weight | 280.36 |
| SMILES | O=C(OCCCCCCCCCC#C)N[C@H]1CNC1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.