Fig. 1 · Structure
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ARN14988
ACDase Inhibitor
ARN14988 is a potent inhibitor of acid ceramidase (ACDase), demonstrating an IC50 value of 12.8 nM for the human enzyme. This compound effectively modulates sphingolipid metabolism by disrupting ceramide degradation, thereby impacting various cellular processes. ARN14988 is valuable for research applications focused on understanding ACDase's role in disease pathology and potential therapeutic strategies involving ceramide signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1502027-70-4 |
| Applications | ACDase Inhibitor |
| Formula | C16H24ClN3O5 |
| Molecular Weight | 373.83 |
| SMILES | O=C(N(C1=O)C(C(Cl)=CN1C(NCCCCCC)=O)=O)OCC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.