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Aromatase-IN-1

Aromatase Inhibitor

Aromatase-IN-1 is a competitive inhibitor of aromatase (P450arom), exhibiting a human IC50 of 40 nM and a Ki of 1.05 nM. It functions by coordinating the imidazole nitrogen to the heme iron of the aromatase enzyme. This compound is primarily utilized in research focused on breast cancer, aiding in the understanding and potential treatment of estrogen-dependent tumors.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	331684-05-0
Applications	Aromatase Inhibitor
Formula	C₁₇H₁₁N₃O₄
Molecular Weight	321.29
SMILES	O=C1C2=C(OC3=C1C([N+]([O-])=O)=CC=C3CN4C=NC=C4)C=CC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.