Fig. 1 · Structure
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ARRY-382
c-Fm Inhibitor
ARRY-382 is a potent and highly selective inhibitor of CSF1R/c-Fms, exhibiting an IC50 of 9 nM. This compound effectively modulates the macrophage signaling pathway, making it a valuable tool for studying tumor microenvironments. ARRY-382 is primarily utilized in research focused on advanced or metastatic cancers, facilitating investigations into therapeutic strategies targeting macrophage-mediated tumor progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1313407-95-2 |
| Applications | c-Fm Inhibitor |
| Formula | C32H36N8O2 |
| Molecular Weight | 564.68 |
| SMILES | O=C(C1=CN=C2C=C(OCCN3CCN(C)CC3)C=CN21)NC4=CC=CC5=C4C(C6CC6)=NN5CC7=NC(C)=CC=C7 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.