ARS-853

Catalog No.: A12542

KRAS G12C inhibitor

ARS-853

ARS-853 Chemical Structure

CAS NO. 1629268-00-3

ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

Availability: In stock

Package Price Qty
1 mg
$135.00
5 mg
$405.00
10 mg
$690.00
50 mg
$2,070.00
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Biological Activity

ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.
In vitro DMSO Warmed: 80 mg/mL (184.78 mM)
Water Insoluble
Ethanol Warmed: 1 mg/mL (2.3 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.1 mL 115.49 mL 230.98 mL
0.5 mM 4.62 mL 23.1 mL 46.2 mL
1 mM 2.31 mL 11.55 mL 23.1 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

*The above data is based on the productmolecular weight 432.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12542
Actions Inhibitor
CAS No. 1629268-00-3
Formula C22H29ClN4O3
M. Wt 432.94
Purity >98%
Synonyms ARS853, ARS 853
SMILES ClC1=C(C2(C)CC2)C=C(NCC(N3CCN(C4CN(C(C=C)=O)C4)CC3)=O)C(O)=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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