ART5803 is a humanized IgG1 monoclonal antibody that targets the N-terminal domain of the NMDAR GluN1 subunit. This compound effectively inhibits NMDAR internalization induced by pathogenic autoantibodies and restores both cell-surface expression and functional activity of NMDAR. ART5803 has demonstrated efficacy in reversing behavioral abnormalities and restoring NMDAR expression in marmoset models of disease, making it a valuable tool for research on anti-NMDAR encephalitis.
ART5803 is a humanized IgG1 monoclonal antibody that targets the N-terminal domain of the NMDAR GluN1 subunit. This compound effectively inhibits NMDAR internalization induced by pathogenic autoantibodies and restores both cell-surface expression and functional activity of NMDAR. ART5803 has demonstrated efficacy in reversing behavioral abnormalities and restoring NMDAR expression in marmoset models of disease, making it a valuable tool for research on anti-NMDAR encephalitis.
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