Fig. 1 · Structure
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ARUK3001185
Notum Inhibitor
ARUK3001185 is a potent and selective inhibitor of Notum, with an IC50 value of 6.7 nM, and demonstrates oral bioavailability along with brain penetration. This compound effectively restores Wnt signaling in vitro even in the presence of Notum, highlighting its potential in the study of Wnt-related pathways. Its selectivity against serine hydrolases, kinases, and other drug targets makes ARUK3001185 a valuable tool for investigating the role of Notum in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2411969-39-4 |
| Applications | Notum Inhibitor |
| Formula | C9H4Cl2F3N3 |
| Molecular Weight | 282.05 |
| SMILES | FC(F)(C1=C(Cl)C=CC(N2C=CN=N2)=C1Cl)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.