AS-605240

Catalog No.: A10088

PI3K Inhibitor

AS-605240 Chemical Structure

CAS NO. 648450-29-7

AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$100.00
50 mg
$180.00
100 mg
$260.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.
Targets
PI3Kγ (Cell-free assay) PI3Kα (Cell-free assay) PI3Kβ (Cell-free assay) PI3Kδ (Cell-free assay)
8 nM60 nM270 nM300 nM
In vitro (25°C) DMSO 0.4 mg/mL (1.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 11 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.87 mL 194.33 mL 388.65 mL
0.5 mM 7.77 mL 38.87 mL 77.73 mL
1 mM 3.89 mL 19.43 mL 38.87 mL
5 mM 0.78 mL 3.89 mL 7.77 mL

*The above data is based on the productmolecular weight 257.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10088
Actions Inhibitor
M. Wt 257.3
Formula C12H7N3O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 648450-29-7
Synonyms AS605240
SMILES C1=CC2=NC=CN=C2C=C1/C=C\3/C(=O)NC(=O)S3

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