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Biological Activity
AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.
Targets
PI3Kγ (Cell-free assay) | PI3Kα (Cell-free assay) | PI3Kβ (Cell-free assay) | PI3Kδ (Cell-free assay) | |
8 nM | 60 nM | 270 nM | 300 nM |
In vitro (25°C) | DMSO | 0.38 mg/mL (1.47 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 0.5% CMC+0.25% Tween 80 | 10 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 38.87 mL | 194.33 mL | 388.65 mL |
0.5 mM | 7.77 mL | 38.87 mL | 77.73 mL |
1 mM | 3.89 mL | 19.43 mL | 38.87 mL |
5 mM | 0.78 mL | 3.89 mL | 7.77 mL |
*The above data is based on the productmolecular weight 257.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10088 |
---|---|
Actions | Inhibitor |
CAS No. | 648450-29-7 |
Formula | C12H7N3O2S |
M. Wt | 257.3 |
Purity | >98% |
Synonyms | AS605240 |
SMILES | C1=CC2=NC=CN=C2C=C1/C=C\3/C(=O)NC(=O)S3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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