Fig. 1 · Structure
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AS1134900
ME1 Inhibitor
AS1134900 is a selective uncompetitive allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1), exhibiting an IC50 of 0.73 μM. This reagent is valuable for investigating the role of ME1 in metabolic processes associated with cancer. Its use may enhance understanding of tumor metabolism and aid in the development of targeted therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 149760-98-5 |
| Applications | ME1 Inhibitor |
| Formula | C25H22N8S |
| Molecular Weight | 466.56 |
| SMILES | CCCC1=NC2=C(C)C=CN(CC3=CC=C4N=C(C5=CC=CC=C5C6=NN=NN6)SC4=C3)C2=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.