Fig. 1 · Structure
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AS19
5-HT7 Receptor Agonist
AS19 is a highly potent and selective agonist of the 5-HT7 receptor, with an IC50 value of 0.83 nM and a Ki of 0.6 nM. It demonstrates significant selectivity over other serotonin receptors, including 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A, with Kis values ranging from 6.6 nM to 490 nM. AS19 has been shown to enhance memory consolidation and effectively reverse amnesia induced by Scopolamine or Dizocilpine, making it a valuable tool for research in cognitive function and neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1000578-26-6 |
| Applications | 5-HT7 Receptor Agonist |
| Formula | C18H25N3 |
| Molecular Weight | 283.41 |
| SMILES | CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.