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AS2795440

PIKfyve Inhibitor

AS2795440 is a selective PIKfyve inhibitor that effectively reduces the production of proinflammatory cytokines such as IL-12p40 and IL-6, while preserving calcium signaling pathways. This compound has demonstrated a significant reduction in joint inflammation and bone loss in a mouse model of adjuvant-induced arthritis. AS2795440 is applicable in research involving inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2171506-45-7
Applications	PIKfyve Inhibitor
Formula	C₂₉H₃₂N₆O
Molecular Weight	480.60
SMILES	CC(NC1=C2N=C(C(NC3=C(N=CC(C4=CC=C(N=C4)C(CC5)=CCN5C(C)C)=C3)C)=O)C=C1)=C2C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.