Fig. 1 · Structure
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Asfotase alfa
Anti-HPP Agent
Asfotase alfa is a genetically engineered glycoprotein targeting hypophosphatasia (HPP). It enhances bone mineralization, increases survival rates, and promotes bone length in model systems, specifically demonstrating efficacy in Akp2 knockout mice by preventing mineralization defects in critical skeletal areas. This reagent is valuable for research investigating perinatal, infantile, and juvenile-onset HPP, facilitating insights into therapeutic strategies for this condition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1174277-80-5 |
| Applications | Anti-HPP Agent |
| Molecular Weight | 161.135 kDa |
| Synonyms | ENB-0040 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.