Fig. 1 · Structure
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ASP2535
GlyT1 Inhibitor
ASP2535 is a selective inhibitor of the glycine transporter-1 (GlyT1), demonstrating potent activity and oral bioavailability. This compound effectively crosses the blood-brain barrier and has been shown to improve cognitive impairment in preclinical models of schizophrenia and Alzheimer's disease, making it valuable for neurological research and potential therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 374886-51-8 |
| Applications | GlyT1 Inhibitor |
| Formula | C22H18N6O |
| Molecular Weight | 382.42 |
| SMILES | CC(C1=NN=C(C2=CC=C(C3=CC=CC=C3)N=C2)N1C4=CC=CC5=NON=C54)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.