Fig. 1 · Structure
Documents & Downloads
Aspulvinone O
GOT1 Inhibitor
Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase 1 (GOT1), targeting glutamine metabolism. This compound effectively reduces NADPH production, leading to oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O demonstrates significant inhibition of PDAC cell proliferation in vitro and reduces tumor growth in xenograft models, making it a valuable tool for cancer research and therapeutic analysis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 914071-54-8 |
| Applications | GOT1 Inhibitor |
| Formula | C27H28O6 |
| Molecular Weight | 448.51 |
| SMILES | OC1=C(C2=CC(C/C=C(C)/C)=C(O)C=C2O)C(O/C1=C/C3=CC(C/C=C(C)/C)=C(O)C=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.