Astressin 2B is a selective antagonist of the corticotropin-releasing factor receptor 2 (CRFR2) with an IC50 of 0.57 nM. This compound disrupts the protective effects mediated by CRFR2, leading to increased intestinal damage in models of hemorrhagic injury and suggesting potential roles in studying inflammatory responses. Astressin 2B also reverses the protective effects of Urocortin 1 against intestinal complications and mitigates the anxiogenic effects of Urocortin 2, demonstrating its utility in research related to stress-induced anxiety and gastrointestinal pathology. This reagent is an effective tool for investigating CRFR2's role in intestinal protection and inflammatory processes.
Astressin 2B is a selective antagonist of the corticotropin-releasing factor receptor 2 (CRFR2) with an IC50 of 0.57 nM. This compound disrupts the protective effects mediated by CRFR2, leading to increased intestinal damage in models of hemorrhagic injury and suggesting potential roles in studying inflammatory responses. Astressin 2B also reverses the protective effects of Urocortin 1 against intestinal complications and mitigates the anxiogenic effects of Urocortin 2, demonstrating its utility in research related to stress-induced anxiety and gastrointestinal pathology. This reagent is an effective tool for investigating CRFR2's role in intestinal protection and inflammatory processes.
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