Fig. 1 · Structure
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Asundexian
FXIa Inhibitor
Asundexian is a potent and selective inhibitor of coagulation factor XIa (FXIa) that functions through direct and reversible binding to the enzyme's active site. This compound demonstrates significant inhibitory activity against human FXIa, with an IC50 value of 1 nM in buffered conditions. Asundexian is primarily used in research applications related to thromboembolism and coagulation disorders, making it a valuable tool for advancing the understanding of blood coagulation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2064121-65-7 |
| Applications | FXIa Inhibitor |
| Formula | C26H21ClF4N6O4 |
| Molecular Weight | 592.93 |
| Synonyms | BAY-2433334 |
| SMILES | COC(C(C1=C(N2C=C(N=N2)C(F)(F)F)C=CC(Cl)=C1)=C3)=CN([C@@H](CC)C(NC4=CC(F)=C(C=C4)C(N)=O)=O)C3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.