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AT1R antagonist 3

AT1R Antagonist

AT1R antagonist 3 is a potent antagonist of the angiotensin II type 1 receptor (AT1R) and an inhibitor of the L-type calcium channel CaV1.2 with an IC50 of 0.57 μM. This compound demonstrates significant vasodilatory effects in isolated rat aorta at a concentration of 10 μM, achieving an 88.7% vasodilation rate. Additionally, it exhibits antihypertensive properties in rat models, making it a valuable tool for research in cardiovascular and hypertension studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3053482-15-5
Applications	AT1R Antagonist
Formula	C₂₂H₁₆N₆O₂S
Molecular Weight	428.47
SMILES	O=C(C1=CC2=C(NC(SCC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=N2)C=C1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.