Fig. 1 · Structure
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AT2R antagonist 1
AT2R Antagonist
AT2R Antagonist 1 is a selective ligand targeting the angiotensin II AT2 receptor (AT2R) with a binding affinity characterized by a Ki value of 29 nM. This compound demonstrates significant inhibitory effects on various cytochrome P450 (CYP) enzymes involved in drug metabolism. Additionally, AT2R Antagonist 1 exhibits exceptional stability in liver microsomes derived from human, rat, and mouse sources, making it a valuable reagent for studies on cardiovascular and renal research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2709031-17-2 |
| Applications | AT2R Antagonist |
| Formula | C23H30N4O4S2 |
| Molecular Weight | 490.64 |
| SMILES | COC(NS(=O)(C1=C(N=C(S1)CC(C)C)C2=CC=C(C=C2)CN3C=CN=C3C(C)(C)C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.