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CDK Inhibitor

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Catalog No. A10093

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT7519 5mg A10093-5

Regular Price: $70.00

Special Price: $63.00

AT7519 10mg A10093-10
AT7519 25mg A10093-25

Regular Price: $220.00

Special Price: $198.00

AT7519 50mg A10093-50

Regular Price: $380.00

Special Price: $342.00

AT7519 100mg A10093-100

Regular Price: $620.00

Special Price: $558.00

AT7519 10mM * 1mL in DMSO A10093-10mM-D

Regular Price: $113.00

Special Price: $101.70

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.


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Chemical Information

Catalog Num A10093
Actions Inhibitor
M. Wt 382.2
Formula C16H17Cl2N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 844442-38-2
Synonyms AT-7519

Biological Activity

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
Target Value
CDK9/CyclinTIC50: <10nM
CDK5/p35IC50: 13nM
CDK2/CyclinAIC50: 47nM
GSK-3βIC50: 89nM
CDK4/CyclinD1IC50: 100nM
CDK6/CyclinD3IC50: 170nM
CDK1/CyclinBIC50: 210nM
CDK3/CyclinEIC50: 360nM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
TrkBIC50: >1μM
JAK2IC50: >1μM
CDK7/CyclinH/MAT1IC50: 2.4μM
SAPK2A(p38α)IC50: >10μM
p70S6KIC50: >10μM
PDGFRIC50: >10μM
PDK-1IC50: >10μM
PKBβIC50: >10μM
VEGFR1IC50: >10μM
AuroraAIC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
Chk1IC50: >10μM
EGFRIC50: >10μM
FGFR3IC50: >10μM
IRIC50: >10μM
JNK2IC50: >10μM
MAPK1IC50: >10μM
MEK1IC50: >10μM
MetIC50: >10μM


Solubility (25°C) * In vitro DMSO 10 mg/mL (26.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.16 mL 130.82 mL 261.64mL
0.5 mM 5.23 mL 26.16 mL 52.33 mL
1 mM 2.62 mL 13.08 mL 26.16 mL
5 mM 0.52 mL 2.62 mL 5.23 mL

*The above data is based on the productmolecular weight 382.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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