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AT7519

Name: AT7519
Brand: Adooq Bioscience
SKU: A10093
Rating: 100 (268 reviews)

Catalog No.: A10093

CDK Inhibitor

AT7519 Chemical Structure

CAS NO. 844442-38-2

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $55.00 Special Price $44.00
10 mg	Regular Price: $85.00 Special Price $68.00
50 mg	Regular Price: $175.00 Special Price $140.00
100 mg	Regular Price: $240.00 Special Price $192.00
10mM * 1mL in DMSO	Regular Price: $70.00 Special Price $56.00
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

Targets

Target	Value
CDK9/CyclinT	IC50: <10nM
CDK5/p35	IC50: 13nM
CDK2/CyclinA	IC50: 47nM
GSK-3β	IC50: 89nM
CDK4/CyclinD1	IC50: 100nM
CDK6/CyclinD3	IC50: 170nM
CDK1/CyclinB	IC50: 210nM
CDK3/CyclinE	IC50: 360nM
PI3Kβ	IC50: >1μM
PLK3	IC50: >1μM
RET	IC50: >1μM
SGK	IC50: >1μM
TrkB	IC50: >1μM
JAK2	IC50: >1μM
CDK7/CyclinH/MAT1	IC50: 2.4μM
SAPK2A(p38α)	IC50: >10μM
p70S6K	IC50: >10μM
PDGFR	IC50: >10μM
PDK-1	IC50: >10μM
PKBβ	IC50: >10μM
VEGFR1	IC50: >10μM
AuroraA	IC50: >10μM
c-Abl	IC50: >10μM
c-Src	IC50: >10μM
Chk1	IC50: >10μM
EGFR	IC50: >10μM
FGFR3	IC50: >10μM
IR	IC50: >10μM
JNK2	IC50: >10μM
MAPK1	IC50: >10μM
MEK1	IC50: >10μM
Met	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	9 mg/mL (23.54 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.16 mL	130.82 mL	261.64 mL
0.5 mM	5.23 mL	26.16 mL	52.33 mL
1 mM	2.62 mL	13.08 mL	26.16 mL
5 mM	0.52 mL	2.62 mL	5.23 mL

*The above data is based on the productmolecular weight 382.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10093
Actions	Inhibitor
CAS No.	844442-38-2
Formula	C16H17Cl2N5O2
M. Wt	382.2
Purity	>98%
Synonyms	AT-7519
SMILES	C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.