Fig. 1 · Structure
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ATC0065
MCHR1 Antagonist
ATC0065 is a potent and selective antagonist of the melanin-concentrating hormone receptor 1 (MCHR1), exhibiting an IC50 of 15.7 nM against human MCHR1, while showing minimal activity towards MCHR2. This compound demonstrates notable anxiolytic and antidepressant effects, making it a valuable tool for research into anxiety and mood disorders. Its oral bioavailability further enhances its utility in preclinical studies aimed at exploring MCHR1-related pathways and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 510732-84-0 |
| Applications | MCHR1 Antagonist |
| Formula | C25H31BrCl2F3N5O |
| Molecular Weight | 625.35 |
| SMILES | CN(C)C1=C2C=CC=CC2=NC(N[C@H]3CC[C@@H](NCCC4=CC=C(Br)C=C4OC(F)(F)F)CC3)=N1.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.