Fig. 1 · Structure
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ATF4-IN-1
ATF4 Inhibitor
ATF4-IN-1 is a selective inhibitor of ATF4, with additional activity as an eIF2B activator. This compound demonstrates significant potential in modulating the integrated stress response, making it valuable for investigating mechanisms underlying neurodegenerative diseases. Researchers may utilize ATF4-IN-1 to explore therapeutic approaches targeting cellular stress pathways and their role in neuronal degradation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2991057-76-0 |
| Applications | ATF4 Inhibitor |
| Formula | C24H21Cl2N3O4 |
| Molecular Weight | 486.35 |
| SMILES | O=C(N[C@H]1CC[C@H](C2=NN=C(C3=CC4=CC(Cl)=CC=C4O3)O2)CC1)COC5=CC=C(Cl)C=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.