Fig. 1 · Structure
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ATIC-IN-1 acetate
ATIC Inhibitor
ATIC-IN-1 acetate is a potent inhibitor of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). By disrupting ATIC dimerization, essential for its AICAR transformylase activity, this compound demonstrates a Ki value of 685 nM. ATIC-IN-1 acetate exhibits significant anti-tumor activity, effectively reducing cell proliferation and division rates, making it a valuable tool for research in cancer biology and purine metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3067165-96-9 |
| Applications | ATIC Inhibitor |
| Formula | C23H37N7O7 |
| Molecular Weight | 523.58 |
| SMILES | N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O.CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.