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ATIC-IN-1

ATIC Inhibitor

ATIC-IN-1 is a potent inhibitor of the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), exhibiting a Ki value of 685 nM. By inhibiting ATIC dimerization, this compound disrupts its catalytic activity, specifically targeting the AICAR transformylase function. ATIC-IN-1 demonstrates notable anti-tumor activity, characterized by a reduction in both cell proliferation and division rates, making it a valuable tool for cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1402453-15-9
Applications	ATIC Inhibitor
Formula	C₂₁H₃₃N₇O₅
Molecular Weight	463.53
SMILES	N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.