Fig. 1 · Structure
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Atopaxar hydrochloride
PAR-1 Antagonist
Atopaxar hydrochloride is a selective and reversible antagonist of protease-activated receptor-1 (PAR-1) that functions primarily as a thrombin receptor inhibitor. This compound demonstrates significant biological activity by inhibiting Janus kinase 1 (JAK1) and JAK2, resulting in JAK-STAT pathway inhibition with an EC50 of 5.90 μM in A549 cells. It has been shown to decrease cell viability (IC50=7.02 μM), induce apoptosis, and arrest the cell cycle at the G1 phase. Atopaxar hydrochloride is valuable in research focused on atherothrombotic diseases and exhibits both antiplatelet and antitumor properties.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 474544-83-7 |
| Applications | PAR-1 Antagonist |
| Formula | C29H39ClFN3O5 |
| Molecular Weight | 564.09 |
| Synonyms | E5555 hydrochloride; ER-172594-00 hydrochloride |
| SMILES | COC1=C(N2CCOCC2)C=C(C(CN(CC3=C4C(F)=C(OCC)C(OCC)=C3)C4=N)=O)C=C1C(C)(C)C.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.