Atopaxar hydrochloride is a selective and reversible antagonist of protease-activated receptor-1 (PAR-1) that functions primarily as a thrombin receptor inhibitor. This compound demonstrates significant biological activity by inhibiting Janus kinase 1 (JAK1) and JAK2, resulting in JAK-STAT pathway inhibition with an EC50 of 5.90 μM in A549 cells. It has been shown to decrease cell viability (IC50=7.02 μM), induce apoptosis, and arrest the cell cycle at the G1 phase. Atopaxar hydrochloride is valuable in research focused on atherothrombotic diseases and exhibits both antiplatelet and antitumor properties.
Atopaxar hydrochloride is a selective and reversible antagonist of protease-activated receptor-1 (PAR-1) that functions primarily as a thrombin receptor inhibitor. This compound demonstrates significant biological activity by inhibiting Janus kinase 1 (JAK1) and JAK2, resulting in JAK-STAT pathway inhibition with an EC50 of 5.90 μM in A549 cells. It has been shown to decrease cell viability (IC50=7.02 μM), induce apoptosis, and arrest the cell cycle at the G1 phase. Atopaxar hydrochloride is valuable in research focused on atherothrombotic diseases and exhibits both antiplatelet and antitumor properties.
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