Fig. 1 · Structure
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Atorvastatin lactone
HMGCR Inhibitor
Atorvastatin lactone is a prodrug form of atorvastatin, functioning as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This compound exhibits significant lipid-lowering effects through the reduction of cholesterol synthesis in the liver, making it valuable in the study of hyperlipidemia and cardiovascular diseases. Atorvastatin lactone is utilized in various research applications aimed at elucidating the mechanisms of cholesterol regulation and potential therapeutic targets for dyslipidemias.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 125995-03-1 |
| Applications | HMGCR Inhibitor |
| Formula | C33H33FN2O4 |
| Molecular Weight | 540.62 |
| SMILES | O=C(C1=C(C(C)C)N(CC[C@@H]2C[C@@H](O)CC(O2)=O)C(C3=CC=C(F)C=C3)=C1C4=CC=CC=C4)NC5=CC=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.