Fig. 1 · Structure
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Atrial natriuretic factor (1-28) (human, porcine)
POMC Suppressor
Atrial natriuretic factor (1-28) (human, porcine) primarily targets pro-opiomelanocortin (POMC) to exert its biological effects. This peptide demonstrates significant blood pressure-lowering activity by promoting sodium and urine excretion. In addition, it inhibits the secretion of adrenocorticotropic hormone (ACTH) and beta-endorphin, resulting from reduced POMC expression. Atrial natriuretic factor (1-28) (human, porcine) also elevates levels of cGMP in renal medullary interstitial cells (RMIC), with an IC50 of 1.2 nM, making it useful for research in cardiovascular and endocrine functions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 91917-63-4 |
| Applications | POMC Suppressor |
| Formula | C127H205N45O39S3 |
| Molecular Weight | 3080.46 |
| Synonyms | Atrial natriuretic peptide (1-28) |
| SMILES | CCC(C)C1NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)C(Cc2ccccc2)NC(=O)C(CSSCC(NC(=O)CNC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CO)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc1ccc(O)cc1)C(O)=O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(N)CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.