Fig. 1 · Structure
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Atuveciclib S-Enantiomer
CDK Inhibitor
Atuveciclib S-Enantiomer is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9). With an IC50 of 16 nM, it effectively inhibits the CDK9/CycT1 complex, playing a crucial role in regulating transcription and cell cycle progression. This compound is primarily utilized in research applications targeting cancer therapeutics and studying transcriptional regulation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2250279-81-1 |
| Applications | CDK Inhibitor |
| Formula | C18H18FN5O2S |
| Molecular Weight | 387.43 |
| Synonyms | BAY-1143572 S-Enantiomer |
| SMILES | N=[S@@](CC1=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=CC=C1)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.