Fig. 1 · Structure
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Aurora kinase-IN-3
AURKB Inhibitor
Aurora kinase-IN-3 is an orally active AURKB inhibitor that disrupts the mitotic localization of AURKB, effectively suppressing its activity. Unlike traditional inhibitors, this compound does not primarily target the phosphorylation of histone H3 at Ser10. Its unique mechanism of action makes it valuable for research in cellular division, cancer therapy, and the exploration of mitotic regulation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2840558-83-8 |
| Applications | AURKB Inhibitor |
| Formula | C20H16F3N3O4 |
| Molecular Weight | 419.35 |
| SMILES | CNC(C1=CC(OC(F)(F)F)=CC(OC2=C(C=CC=N2)C3=CC(OC)=NC=C3)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.