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Aurora kinase ligand-1

AURKB PROTAC Ligand

Aurora kinase ligand-1 is a targeted ligand for Aurora kinase B (AURKB) utilized in PROTAC (Proteolysis Targeting Chimeras) applications. This compound can be conjugated with an E3 ligase ligand and a linker to create the AURKB PROTAC degrader, MS44. Aurora kinase ligand-1 is instrumental in cancer research, facilitating the degradation of AURKB, thereby offering potential therapeutic avenues for malignancies associated with dysregulated kinase activity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1907679-70-2
Applications	AURKB PROTAC Ligand
Formula	C₂₄H₂₆FN₇O₃
Molecular Weight	479.51
SMILES	OCCNCCCOC1=CC2=NC=NC(NC3=NNC(CC(NC4=CC=CC(F)=C4)=O)=C3)=C2C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.