Fig. 1 · Structure
Documents & Downloads
AV-153 free base
Antimutagenic
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, functions as an antimutagenic agent. It effectively intercalates into DNA, mitigating single-strand breaks and promoting DNA repair in human cells in vitro. Additionally, AV-153 free base interacts specifically with thymine and cytosine, influencing poly(ADP)ribosylation pathways. This compound also exhibits notable anti-cancer activity, making it a valuable tool for research in cancer biology and DNA damage response studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 19350-66-4 |
| Applications | Antimutagenic |
| Formula | C14H19NO6 |
| Molecular Weight | 297.30 |
| SMILES | O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C(O)=O)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.