AV-412

Catalog No.: A11028

EGFR inhibitor

AV-412

AV-412 Chemical Structure

CAS NO. 451493-31-5

AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis.

Availability: In stock

Package Price Qty
2 mg
$60.00
5 mg
$99.00
10 mg
$165.00
50 mg
$495.00
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  • Le Zhang, .et al. High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor, Oncotarget, 2016, Apr 12; 7(15): 19948-19959 PMID: 26942566

Biological Activity

AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.75 mL 58.73 mL 117.45 mL
0.5 mM 2.35 mL 11.75 mL 23.49 mL
1 mM 1.17 mL 5.87 mL 11.75 mL
5 mM 0.23 mL 1.17 mL 2.35 mL

*The above data is based on the productmolecular weight 851.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11028
Actions Inhibitor
CAS No. 451493-31-5
Formula C27H28ClFN6O.2C7H8O3S
M. Wt 851.4
Purity >98%
Synonyms AV412, MP-412
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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