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AV-412

EGFR inhibitor

158 Customer Reviews
Catalog No. A11028

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AV-412 2mg A11028-2
$60.00
AV-412 5mg A11028-5
$99.00
AV-412 10mg A11028-10
$165.00
AV-412 50mg A11028-50
$495.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis.

AV-412

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Publications citing Adooq Products
AV-412 Citations (1)
  • Le Zhang, .et al. High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor, Oncotarget, 2016, Apr 12; 7(15): 19948每19959 PMID: 26942566

Chemical Information

Catalog Num A11028
Actions Inhibitor
M. Wt 851.4
Formula C27H28ClFN6O.2C7H8O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 451493-31-5
Synonyms AV412, MP-412
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C
Chemical Name 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-methylbenzenesulfonate

Biological Activity

Description
 AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.75 mL 58.73 mL 117.45mL
0.5 mM 2.35 mL 11.75 mL 23.49 mL
1 mM 1.17 mL 5.87 mL 11.75 mL
5 mM 0.23 mL 1.17 mL 2.35 mL

*The above data is based on the productmolecular weight 851.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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