AV412

Catalog No.: A15460

EGFR inhibitor

AV412

AV412 Chemical Structure

CAS NO. 451492-95-8

AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M?and ErbB2, respectively.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$165.00
50 mg
$490.00
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Biological Activity

AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M?and ErbB2, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.72 mL 98.62 mL 197.23 mL
0.5 mM 3.94 mL 19.72 mL 39.45 mL
1 mM 1.97 mL 9.86 mL 19.72 mL
5 mM 0.39 mL 1.97 mL 3.94 mL

*The above data is based on the productmolecular weight 507.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15460
Actions Inhibitor
M. Wt 507.02
Formula C27H28ClFN6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 451492-95-8
Synonyms av 412, av-412, MP 412, MP-412
SMILES O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O

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