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Avanafil metabolite M4

Avanafil Metabolite

Avanafil metabolite M4 is a primary active metabolite of the selective phosphodiesterase-5 (PDE-5) inhibitor, Avanafil. It targets PDE-5 and exhibits significant biological activity by inhibiting cGMP hydrolysis, leading to increased cGMP levels which activates the NO/cGMP/PKG signaling pathway. This metabolite is relevant for research applications in the context of erectile dysfunction and osteoporosis, as it helps to mitigate bone mineral density loss, bone atrophy, and oxidative stress.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2656442-91-8
Applications	Avanafil Metabolite
Formula	C₂₃H₂₆ClN₇O₄
Molecular Weight	499.95
SMILES	COC1=CC=C(C=C1Cl)CNC2=NC(N3C[C@@H](C[C@H]3CO)O)=NC=C2C(NCC4=NC=CC=N4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.