Avapritinib
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | Avapritinib (BLU-285) is a highly potent, selective, and orally bioavailable KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. |
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Catalog Num | A19505 |
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Formula | C26H27FN10 |
Molecular Weight | 498.56 |
CAS Number | 1703793-34-3 |
SMILES | CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1 |
Synonyms | BLU-285, BLU 285, BLU285 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 61 mg/mL (122.35 mM) | |
Water | Insoluble | ||
Ethanol | 3 mg/mL | ||
In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 20.06 mL | 100.29 mL | 200.58 mL |
0.5 mM | 4.01 mL | 20.06 mL | 40.12 mL |
1 mM | 2.01 mL | 10.03 mL | 20.06 mL |
5 mM | 0.4 mL | 2.01 mL | 4.01 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2