Fig. 1 · Structure
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AVN-211
5HT6R Antagonist
AVN-211 is a selective and orally bioavailable antagonist of the 5HT6 receptor, demonstrating an IC50 of 2.34 nM and a Ki of 1.09 nM. This compound exhibits a remarkable 5K-fold selectivity for the 5HT6 receptor over a range of 65 other receptors, enzymes, and ion channels. AVN-211 has been shown to significantly enhance cognitive functions and reduce anxiety-related behaviors in various animal models of Alzheimer's disease, making it a valuable tool for research into Alzheimer's dementia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1173103-84-8 |
| Applications | 5HT6R Antagonist |
| Formula | C15H15N3O2S2 |
| Molecular Weight | 333.43 |
| SMILES | O=S(C1=C2N=C(C)C=C(C)N2N=C1SC)(C3=CC=CC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.