AVN-211 is a selective and orally bioavailable antagonist of the 5HT6 receptor, demonstrating an IC50 of 2.34 nM and a Ki of 1.09 nM. This compound exhibits a remarkable 5K-fold selectivity for the 5HT6 receptor over a range of 65 other receptors, enzymes, and ion channels. AVN-211 has been shown to significantly enhance cognitive functions and reduce anxiety-related behaviors in various animal models of Alzheimer's disease, making it a valuable tool for research into Alzheimer's dementia.
AVN-211 is a selective and orally bioavailable antagonist of the 5HT6 receptor, demonstrating an IC50 of 2.34 nM and a Ki of 1.09 nM. This compound exhibits a remarkable 5K-fold selectivity for the 5HT6 receptor over a range of 65 other receptors, enzymes, and ion channels. AVN-211 has been shown to significantly enhance cognitive functions and reduce anxiety-related behaviors in various animal models of Alzheimer's disease, making it a valuable tool for research into Alzheimer's dementia.
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