Fig. 1 · Structure
Documents & Downloads
AVP-13358
IgE Inhibitor
AVP-13358 is an orally active inhibitor of immunoglobulin E (IgE) that effectively suppresses IgE-mediated immune responses. It displays IC50 values of 8 nM in vivo and 3 nM in vitro for IgE inhibition, specifically acting on T cells to inhibit the production and release of IL-4, IL-5, and IL-13. Additionally, AVP-13358 targets critical markers for allergic response development, such as the B cell IgE receptor (CD23) in human monocytes and CD23 and IL-4 receptors in mouse B cells. This compound is useful for research investigating anti-allergic therapies and immune modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 459805-03-9 |
| Applications | IgE Inhibitor |
| Formula | C30H29N5O2 |
| Molecular Weight | 491.58 |
| SMILES | O=C(C1=CC=C2N=C(C3=CC=C(NC(C45CC6CC(C5)CC(C4)C6)=O)C=C3)NC2=C1)NC7=NC=CC=C7 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.