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AX-9657

NE Inhibitor

AX-9657 is a potent inhibitor of neutrophil elastase (NE) that targets inflammation pathways in pulmonary disorders. This compound demonstrates significant efficacy in reducing lung inflammation, evidenced by decreased neutrophil counts and cytokine levels, including interleukin 1β and macrophage inflammatory protein 2, in bronchoalveolar lavage fluid. AX-9657 is suitable for research focused on severe pneumonia and related inflammatory conditions, offering insights into therapeutic interventions for lung disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1015439-77-6
Applications	NE Inhibitor
Formula	C₂₂H₂₆N₄O₃
Molecular Weight	394.47
SMILES	O=C1OC(C2=CC=CN=C2N3C[C@@H](N(C)C)CC3)=NC4=CC(OC)=CC(CC)=C14

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.