Fig. 1 · Structure
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Axitinib-d3
Deuterium Labeled Axitinib
Axitinib-d3 is a deuterium-labeled analogue of Axitinib, a multi-targeted tyrosine kinase inhibitor. It demonstrates potent inhibitory activity with IC50 values of 0.1 nM for VEGFR1, 0.2 nM for VEGFR2, 0.1-0.3 nM for VEGFR3, and 1.6 nM for PDGFRβ. This labeled compound is particularly useful for pharmacokinetic studies and can aid in elucidating the mechanistic pathways involved in angiogenesis and tumor growth.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1126623-89-9 |
| Applications | Deuterium Labeled Axitinib |
| Formula | C22H15D3N4OS |
| Molecular Weight | 389.49 |
| Synonyms | AG-013736-d3 |
| SMILES | O=C(NC([2H])([2H])[2H])C1=CC=CC=C1SC2=CC3=C(C=C2)C(/C=C/C4=NC=CC=C4)=NN3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.