You have no items in your shopping cart.
Publications citing Adooq Products
Axitinib Citations (1)
- Youcef M. Rustum, .et al. Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy, Int J Mol Sci, 2018, Nov; 19(11): 3378 PMID: 30380599
Chemical Information
| Catalog Num | A10103 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 386.5 |
| Formula | C22H18N4OS |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 319460-85-0 |
| Synonyms | AG 013736 |
| SMILES | CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4 |
Description |
Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). | ||||||||||||||||||||
Targets |
|
||||||||||||||||||||
| Solubility (25°C) * | In vitro | DMSO | 35 mg/mL heating (90.56 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% CMC | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.87 mL | 129.37 mL | 258.73mL |
| 0.5 mM | 5.17 mL | 25.87 mL | 51.75 mL |
| 1 mM | 2.59 mL | 12.94 mL | 25.87 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
*The above data is based on the productmolecular weight 386.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$45.00
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tu ...
Special Price Starting at: $45.00
Special Price Starting at:
$45.00
Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibitor. ...
Special Price Starting at: $45.00
Special Price Starting at:
$99.00
E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinas ...
Special Price Starting at: $99.00
Special Price Starting at:
$36.00
BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR. ...
Special Price Starting at: $36.00
Special Price Starting at:
$45.00
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases. ...
Special Price Starting at: $45.00
Special Price Starting at:
$60.00
SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. ...
Special Price Starting at: $60.00
Special Price Starting at:
$150.00
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, i ...
Special Price Starting at: $150.00
Special Price Starting at:
$90.00
ZM 306416 is a VEGF receptor tyrosine kinase inhibitor that inhibits KDR (IC50 = 100 nM) and Flt (IC50 = 2 uM) tyrosine kinases. ...
Special Price Starting at: $90.00
Special Price Starting at:
$81.00
NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. ...
Special Price Starting at: $81.00
Special Price Starting at:
$108.00
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers. ...
Special Price Starting at: $108.00
Special Price Starting at:
$81.00
OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. ...
Special Price Starting at: $81.00
Special Price Starting at:
$81.00
Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ.
...
Special Price Starting at: $81.00
Special Price Starting at:
$81.00
Crenolanib (CP-868596) is an orally bioavailable, selective small molecule inhibitor of the PDGFR tyrosine kinase, inhibiting both PDGFRA and PDGFRB at picomolar concentrations. ...
Special Price Starting at: $81.00
Special Price Starting at:
$49.50
Buflomedil is a vasoactive agent used to treat peripheral vascular disease. ...
Special Price Starting at: $49.50
Special Price Starting at:
$280.00
SU10944 is a small molecule kinase inhibitor of VEGFR that inhibits neovascularization and permeability, and is distributed to the eye upon systemic delivery. ...
Special Price Starting at: $280.00
Special Price Starting at:
$54.00
XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. ...
Special Price Starting at: $54.00
Special Price Starting at:
$90.00
Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell m ...
Special Price Starting at: $90.00
Special Price Starting at:
$36.00
Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEG ...
Special Price Starting at: $36.00
Special Price Starting at:
$90.00
Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling. ...
Special Price Starting at: $90.00
Special Price Starting at:
$250.00
BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases. ...
Special Price Starting at: $250.00
Special Price Starting at:
$190.00
E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. ...
Special Price Starting at: $190.00
Special Price Starting at:
$54.00
Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. ...
Special Price Starting at: $54.00
Special Price Starting at:
$200.00
Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. ...
Special Price Starting at: $200.00
Special Price Starting at:
$63.00
SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. ...
Special Price Starting at: $63.00
Special Price Starting at:
$45.00
Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activit ...
Special Price Starting at: $45.00
Special Price Starting at:
$45.00
Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays. ...
Special Price Starting at: $45.00
Special Price Starting at:
$220.00
TG 100572 is VEGFR2 and Src kinase inhibitor. ...
Special Price Starting at: $220.00
Special Price Starting at:
$36.00
Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and ...
Special Price Starting at: $36.00
Special Price Starting at:
$135.00
(-)-Catechin gallate is an antioxidant constituent of green tea. At uM concentrations, inhibits VEGF-induced tyrosine phosphorylation. ...
Special Price Starting at: $135.00
Special Price Starting at:
$36.00
Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors. ...
Special Price Starting at: $36.00
Keywords:buy Axitinib | Axitinib Supplier | purchase Axitinib | Axitinib cost | Axitinib manufacturer | order Axitinib | Axitinib distributor | buy 319460-85-0| 319460-85-0 Supplier | purchase 319460-85-0 | 319460-85-0 cost | 319460-85-0 manufacturer | order 319460-85-0 | 319460-85-0 distributor
We Using Safe Payments:
