Total item
Cart Subtotal
$0.00 - Youcef M. Rustum, .et al. Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy, Int J Mol Sci, 2018, Nov; 19(11): 3378 PMID: 30380599
Biological Activity
Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
Targets
| Target | Value |
|---|---|
| VEGFR1/FLT1 | IC50: 0.1nM |
| VEGFR2/Flk1 | IC50: 0.18nM |
| VEGFR2/KDR | IC50: 0.2nM |
| VEGFR3 | IC50: 0.1nM-0.3nM |
| PDGFRβ | IC50: 1.6nM |
| Kit | IC50: 1.7nM |
| PDGFRα | IC50: 5.0nM |
| CSF-1R | IC50: 73nM |
| FLT3 | IC50: >1μM |
| In vitro | DMSO | Warmed: 30 mg/mL (77.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.87 mL | 129.37 mL | 258.73 mL |
| 0.5 mM | 5.17 mL | 25.87 mL | 51.75 mL |
| 1 mM | 2.59 mL | 12.94 mL | 25.87 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
*The above data is based on the productmolecular weight 386.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10103 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 319460-85-0 |
| Formula | C22H18N4OS |
| M. Wt | 386.5 |
| Purity | >98% |
| Synonyms | AG 013736 |
| SMILES | CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an ora…
Taxifolin
Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibi…
E-7050 (Golvatinib)
E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (v…
Bibf1120 (Nintedanib)
BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR…
E7080 (Lenvatinib)
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
SKLB1002
SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
ZM 306416
ZM 306416 is a VEGF receptor tyrosine kinase inhibitor that inhibits KDR (IC50 = 100 nM) and Flt (IC50 = 2 uM) tyrosine kinases.
Keywords:buy Axitinib | Axitinib Supplier | purchase | cost | manufacturer | order | distributor | buy 319460-85-0| 319460-85-0 Supplier | purchase 319460-85-0 | 319460-85-0 cost | 319460-85-0 manufacturer | order 319460-85-0 | 319460-85-0 distributor
Adooq Quality Guarantee
We promise all products perform as described.