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Publications citing Adooq Products
Axitinib Citations (1)
- Youcef M. Rustum, .et al. Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma〞Bench-to-Bedside Therapy, Int J Mol Sci, 2018, Nov; 19(11): 3378 PMID: 30380599
Chemical Information
| Catalog Num | A10103 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 386.5 |
| Formula | C22H18N4OS |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 319460-85-0 |
| Synonyms | AG 013736 |
| SMILES | CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4 |
| Chemical Name | N-Methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide |
Description |
Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). | ||||||||||||||||||||
Targets |
|
||||||||||||||||||||
| Solubility (25°C) * | In vitro | DMSO | 35 mg/mL heating (90.56 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% CMC | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.87 mL | 129.37 mL | 258.73mL |
| 0.5 mM | 5.17 mL | 25.87 mL | 51.75 mL |
| 1 mM | 2.59 mL | 12.94 mL | 25.87 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
*The above data is based on the productmolecular weight 386.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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