Axitinib

Catalog No.: A10103

VEGFR inhibitor

Axitinib

Axitinib Chemical Structure

CAS NO. 319460-85-0

Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).

Availability: In stock

Package Price Qty
50 mg

Regular Price: $40.00

Special Price $32.00

100 mg

Regular Price: $70.00

Special Price $56.00

250 mg

Regular Price: $120.00

Special Price $96.00

10mM * 1mL in DMSO
$62.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
Targets
Target Value
VEGFR1/FLT1IC50: 0.1nM
VEGFR2/Flk1IC50: 0.18nM
VEGFR2/KDRIC50: 0.2nM
VEGFR3IC50: 0.1nM-0.3nM
PDGFRβIC50: 1.6nM
KitIC50: 1.7nM
PDGFRαIC50: 5.0nM
CSF-1RIC50: 73nM
FLT3IC50: >1μM
In vitro (25°C) DMSO 35 mg/mL heating (90.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.87 mL 129.37 mL 258.73 mL
0.5 mM 5.17 mL 25.87 mL 51.75 mL
1 mM 2.59 mL 12.94 mL 25.87 mL
5 mM 0.52 mL 2.59 mL 5.17 mL

*The above data is based on the productmolecular weight 386.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10103
Actions Inhibitor
M. Wt 386.5
Formula C22H18N4OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 319460-85-0
Synonyms AG 013736
SMILES CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy Axitinib | Axitinib Supplier | purchase Axitinib | Axitinib cost | Axitinib manufacturer | order Axitinib | Axitinib distributor | buy 319460-85-0| 319460-85-0 Supplier | purchase 319460-85-0 | 319460-85-0 cost | 319460-85-0 manufacturer | order 319460-85-0 | 319460-85-0 distributor
Rewards