Fig. 1 · Structure
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AXKO-0046
LDHB Inhibitor
AXKO-0046 is an indole derivative that functions as an uncompetitive inhibitor of Lactate dehydrogenase B (LDHB). With an EC50 value of 42 nM, AXKO-0046 demonstrates potent inhibitory activity against LDHB. This compound is valuable for research into cancer metabolism and its implications in metabolic reprogramming within tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3103525-82-9 |
| Applications | LDHB Inhibitor |
| Formula | C25H33N3 |
| Molecular Weight | 375.55 |
| SMILES | C1(NCC(N2)=C(CCNCC3=CC=CC=C3)C4=C2C=CC=C4)CCCCCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.