Fig. 1 · Structure
Documents & Downloads
AXL-IN-13
AXL Inhibitor
AXL-IN-13 is a potent and orally bioavailable inhibitor of AXL, exhibiting an IC50 of 1.6 nM and a Kd of 0.26 nM. This compound effectively reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and demonstrates significant inhibition of cancer cell migration and invasion. AXL-IN-13 serves as a valuable tool for studying the role of AXL signaling in cancer progression and metastasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2376928-82-2 |
| Applications | AXL Inhibitor |
| Formula | C34H41FN6O5 |
| Molecular Weight | 632.72 |
| SMILES | COC1=C(C=C(C2=C1)N=CC=C2OC3=C(C=C(C=C3)NC4=NN(C=C4C(NC5CCCCC5)=O)C)F)OCCCN6CCOCC6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.