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Axl-IN-21

AXL Inhibitor

Axl-IN-21 is a selective, orally active inhibitor targeting the AXL receptor tyrosine kinase with a Kd of 2.7 nM and an IC50 of 4.0 nM. It demonstrates significant kinase selectivity and exhibits potent activity against various cancer-related multikinases, including Mer (Kd = 1.4 nM) and DDR1 (IC50 = 22.2 nM). Axl-IN-21 effectively blocks GAS6-induced AXL/STAT3/ABCG1 signaling, which enhances chemosensitivity and mitigates drug efflux in gastric cancer. Furthermore, this compound inhibits TGF-β1-mediated epithelial-mesenchymal transition, migration, and invasion in MDA-MB-231 cells, while showing minimal cytotoxicity to non-cancerous cells, making it a promising candidate for research in triple-negative breast cancer and gastric cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1958081-87-2
Applications	AXL Inhibitor
Formula	C₃₀H₂₇FN₄O₅
Molecular Weight	542.56
SMILES	COC1=CC2=C(N=CN=C2OC3=CC=C(C=C3F)NC(C4=C(N(C5=C(C4=O)C=C(C=C5)CC)C)C)=O)C=C1OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.