Fig. 1 · Structure
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AZ 12216052
mGluR8 PAM
AZ 12216052 is a positive allosteric modulator of the metabotropic glutamate receptor 8 (mGluR8), enhancing its signaling in retinal ganglion cells. This compound demonstrates notable antianxiety effects and is useful in research focused on anxiety disorders and retinal signaling pathways. Its modulation of mGluR8 activity makes it a valuable tool for investigating therapeutic strategies in neuropsychiatric and ophthalmologic research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1290628-31-7 |
| Applications | mGluR8 PAM |
| Formula | C19H22BrNOS |
| Molecular Weight | 392.35 |
| SMILES | O=C(CSCC1=CC=C(C=C1)Br)NC2=CC=C(C(CC)C)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.