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AZ-GHS-38

GHS-R1a Inverse Agonist

AZ-GHS-38 is an orally active inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), exhibiting an IC50 of 6.7 nM. This compound effectively reduces food intake in wild-type mice, making it a valuable tool for anti-obesity research. Its central nervous system penetration facilitates investigations into the modulation of appetite and energy homeostasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inverse Agonist
CAS Number	1143021-16-2
Applications	GHS-R1a Inverse Agonist
Formula	C₂₅H₂₈ClN₅O₅S₂
Molecular Weight	578.10
SMILES	O=C(NC1=NC2=C(S1)C=C(S(=O)(C3CCN(CC3)C)=O)C=C2)NC(C4=CC(N5CCOCC5)=CC=C4Cl)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.