AZ12441970 is a potent and selective agonist of Toll-like receptor 7 (TLR7), demonstrating pEC50 values of 6.8 and 6.6 for human and rat TLR7, respectively. This compound exhibits efficacy in a mouse model of allergic airway disease, while inducing minimal systemic IFN-α levels. AZ12441970 serves as a valuable tool for research into allergic airway conditions and TLR7-mediated immune responses.
AZ12441970 is a potent and selective agonist of Toll-like receptor 7 (TLR7), demonstrating pEC50 values of 6.8 and 6.6 for human and rat TLR7, respectively. This compound exhibits efficacy in a mouse model of allergic airway disease, while inducing minimal systemic IFN-α levels. AZ12441970 serves as a valuable tool for research into allergic airway conditions and TLR7-mediated immune responses.
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