Fig. 1 · Structure
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AZ1366
Tankyrase Inhibitor
AZ1366 is a potent orally active inhibitor of tankyrase, a key regulator of the Wnt signaling pathway. By stabilizing Axin2 and reducing NuMA levels, AZ1366 disrupts the tankyrase-NuMA interaction, leading to G2/M phase arrest and downregulation of β-catenin-dependent gene expression. This compound has demonstrated the ability to inhibit tumor growth in colorectal cancer xenograft models, as well as synergistically impair the proliferation of non-small cell lung cancer cells, enhancing tumor control and survival in orthotopic mouse models. AZ1366 is particularly valuable for research focused on colorectal cancer and non-small cell lung cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1645286-58-3 |
| Applications | Tankyrase Inhibitor |
| Formula | C24H24N4O3 |
| Molecular Weight | 416.48 |
| SMILES | O=C1N=C(NC=2C1=CC=CC2CO)C=3C=CC(=CC3)C=4C=NC(=CC4C)NCCOC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.