Fig. 1 · Structure
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AZ1729
FFA2 Activator
AZ1729 is a potent allosteric agonist and positive modulator of the free fatty acid 2 receptor (FFA2). It enhances the activity of the endogenous short-chain fatty acid propionate in Gi-mediated signaling pathways, while exhibiting no effect on Gq/G11 transduction. In addition, AZ1729 has been shown to inhibit isoproterenol-induced lipolysis in mouse adipocytes and promote the migration of human neutrophils. This compound is valuable for studying the physiological roles and signaling pathways associated with FFA2.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2016864-46-1 |
| Applications | FFA2 Activator |
| Formula | C18H16FN5OS |
| Molecular Weight | 369.42 |
| SMILES | O=C(NC1=CC=CC(C2=C(C)N=C(NC(N)=N)S2)=C1)C3=CC=C(F)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.