AZ1729

Catalog No.: A60350
FFA2 Activator
AZ1729 is a potent allosteric agonist and positive modulator of the free fatty acid 2 receptor (FFA2). It enhances the activity of the endogenous short-chain fatty acid propionate in Gi-mediated signaling pathways, while exhibiting no effect on Gq/G11 transduction. In addition, AZ1729 has been shown to inhibit isoproterenol-induced lipolysis in mouse adipocytes and promote the migration of human neutrophils. This compound is valuable for studying the physiological roles and signaling pathways associated with FFA2.
Grouped product items
Size Price Stock Qty
5mg
$255.00
In stock
10mg
$830.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAZ1729 is a potent allosteric agonist and positive modulator of the free fatty acid 2 receptor (FFA2). It enhances the activity of the endogenous short-chain fatty acid propionate in Gi-mediated signaling pathways, while exhibiting no effect on Gq/G11 transduction. In addition, AZ1729 has been shown to inhibit isoproterenol-induced lipolysis in mouse adipocytes and promote the migration of human neutrophils. This compound is valuable for studying the physiological roles and signaling pathways associated with FFA2.
Product Information
Catalog NumA60350
FormulaC18H16FN5OS
Molecular Weight369.42
CAS Number2016864-46-1
SMILESO=C(NC1=CC=CC(C2=C(C)N=C(NC(N)=N)S2)=C1)C3=CC=C(F)C=C3
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