AZ1729 is a potent allosteric agonist and positive modulator of the free fatty acid 2 receptor (FFA2). It enhances the activity of the endogenous short-chain fatty acid propionate in Gi-mediated signaling pathways, while exhibiting no effect on Gq/G11 transduction. In addition, AZ1729 has been shown to inhibit isoproterenol-induced lipolysis in mouse adipocytes and promote the migration of human neutrophils. This compound is valuable for studying the physiological roles and signaling pathways associated with FFA2.
AZ1729 is a potent allosteric agonist and positive modulator of the free fatty acid 2 receptor (FFA2). It enhances the activity of the endogenous short-chain fatty acid propionate in Gi-mediated signaling pathways, while exhibiting no effect on Gq/G11 transduction. In addition, AZ1729 has been shown to inhibit isoproterenol-induced lipolysis in mouse adipocytes and promote the migration of human neutrophils. This compound is valuable for studying the physiological roles and signaling pathways associated with FFA2.
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