AZ304

Catalog No.: A17225

dual BRAF inhibitor

AZ304

AZ304 Chemical Structure

CAS NO. 942507-42-8

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$200.00
50 mg
$750.00
100 mg
$1,200.00
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Biological Activity

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.73 mL 221.47 mL
0.5 mM 4.43 mL 22.15 mL 44.29 mL
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL

*The above data is based on the productmolecular weight 451.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17225
Actions Inhibitor
M. Wt 451.53
Formula C27H25N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 942507-42-8
Synonyms AZ-304; AZ 304;
SMILES O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4

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