AZ304

Catalog No.: A17225

dual BRAF inhibitor

AZ304

AZ304 Chemical Structure

CAS NO. 942507-42-8

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$200.00
50 mg
$750.00
100 mg
$1,200.00
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Biological Activity

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.
In vitro DMSO 81 mg/mL (179.39 mM)
Water Insoluble
Ethanol 5 mg/mL (11.07 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.73 mL 221.47 mL
0.5 mM 4.43 mL 22.15 mL 44.29 mL
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL

*The above data is based on the productmolecular weight 451.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17225
Actions Inhibitor
CAS No. 942507-42-8
Formula C27H25N5O2
M. Wt 451.53
Purity >98%
Synonyms AZ-304; AZ 304;
SMILES O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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