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AZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ).
| In vitro | DMSO | 46 mg/mL (109.39 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.78 mL | 118.91 mL | 237.81 mL |
| 0.5 mM | 4.76 mL | 23.78 mL | 47.56 mL |
| 1 mM | 2.38 mL | 11.89 mL | 23.78 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
*The above data is based on the productmolecular weight 420.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16813 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2088113-98-6 |
| Formula | C24H28N4O3 |
| M. Wt | 420.5 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | AZ 31, AZ-31 |
| SMILES | NC(C1=C(N[[email protected]](C2CCOCC2)C)C3=CC(C4=CN=C(COC)C=C4)=CC=C3N=C1)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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