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Azaspirene

Angiogenesis Inhibitor

Azaspirene is an angiogenesis inhibitor primarily targeting Raf-1 activation. Isolated from the fungus Neosartorya sp., it effectively inhibits vascular endothelial growth factor (VEGF)-induced migration of human umbilical vein endothelial cells (HUVECs) while not affecting the activation of VEGF receptor 2 (KDR/FLK-1). This compound is valuable for research focused on angiogenesis and vascular biology, offering insights into pathways modulated by Raf-1 and their role in endothelial cell behavior.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	461644-34-8
Applications	Angiogenesis Inhibitor
Formula	C₂₁H₂₃NO₅
Molecular Weight	369.41
Synonyms	(-)-Azaspirene
SMILES	O[C@@H]1[C@]2(C(N[C@@]1(O)CC3=CC=CC=C3)=O)OC(/C=C/C=C/CC)=C(C2=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.